Methylamine → 3-Methoxy-N-methyl-4-(7H-purin-8-yl)benzamide

반응식

[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]([NH2:11])=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]1[NH:20][C:19]2[C:14](=[N:15][CH:16]=[N:17][CH:18]=2)[N:13]=1.[CH3:21]N>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]([NH:11][CH3:21])=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]1[NH:20][C:19]2[C:14](=[N:15][CH:16]=[N:17][CH:18]=2)[N:13]=1

참가 물질

반응물 2

HCID 6329Methylamine

HCID 132845313-Methoxy-4-(7H-purin-8-yl)benzamide

생성물 1

HCID 132845323-Methoxy-N-methyl-4-(7H-purin-8-yl)benzamide

실험 절차

Forty milliliters of ethanolic methylamine solution were added to 0.42 gm of 8-(2'-methoxy-4'-chlorocarbonylphenyl)-purine hydrochloride (see Example 43), with cooling, and the mixture was refluxed for 30 minutes. It was then concentrated by evaporation, and the product was purified by column chromatography on silica gel [eluant: methylene chloride/ethanol (8:2)].

후처리

temperaturewith cooling
temperaturethe mixture was refluxed for 30 minutes
concentrationIt was then concentrated by evaporation
customthe product was purified by column chromatography on silica gel [eluant: methylene chloride/ethanol (8:2)]

출처 및 근거

ORD 기록: ord-a4137e4a4a544e069a63a7165fad9f9c
출처 데이터셋: uspto-grants-1986_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04582837

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