Dimethylamine → 8-(2'-Methoxy-4'-dimethylaminosulfonyl-phenyl)-purine hydrochloride

HRID 1380744

반응식

HRID 1380744 반응식
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([S:12]([Cl:15])(=[O:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5](O)=O.[CH3:16][NH:17][CH3:18].[NH2:19][C:20]1[C:25]([NH2:26])=[CH:24][N:23]=[CH:22][N:21]=1>>[ClH:15].[CH3:1][O:2][C:3]1[CH:11]=[C:10]([S:12]([N:17]([CH3:18])[CH3:16])(=[O:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5]1[NH:26][C:25]2[C:20](=[N:21][CH:22]=[N:23][CH:24]=2)[N:19]=1

참가 물질

4

반응물 3

HCID 674DimethylamineHCID 837034,5-DiaminopyrimidineHCID 201845804-(Chlorosulfonyl)-2-methoxybenzoic acid

생성물 1

HCID 201845818-(2'-Methoxy-4'-dimethylaminosulfonyl-phenyl)-purine hydrochloride

실험 절차

Prepared analogously to Example 51 from 2-methoxy-4-chlorosulfonyl-benzoic acid, aqueous dimethylamine solution, and 4,5-diamino-pyrimidine. The hydrochloride was recrystallized from ethanol/water (4:1).

후처리

  1. customThe hydrochloride was recrystallized from ethanol/water (4:1)

출처 및 근거

ORD 기록
ord-124cdc4160634884ae47e8861d091964
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04582837

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