Butylamine → N-Butyl-3-methoxy-4-(7H-purin-8-yl)benzene-1-sulfonamide

HRID 1380746노트

반응식

HRID 1380746 반응식
[CH2:1]([NH2:5])[CH2:2][CH2:3][CH3:4].Cl.[CH3:7][O:8][C:9]1[CH:14]=[C:13]([S:15](Cl)(=[O:17])=[O:16])[CH:12]=[CH:11][C:10]=1[C:19]1[NH:27][C:26]2[C:21](=[N:22][CH:23]=[N:24][CH:25]=2)[N:20]=1>>[CH3:7][O:8][C:9]1[CH:14]=[C:13]([S:15]([NH:5][CH2:1][CH2:2][CH2:3][CH3:4])(=[O:17])=[O:16])[CH:12]=[CH:11][C:10]=1[C:19]1[NH:27][C:26]2[C:21](=[N:22][CH:23]=[N:24][CH:25]=2)[N:20]=1

참가 물질

3

반응물 2

HCID 8007ButylamineHCID 20184500HCID 20184500, 화합물

생성물 1

HCID 13284538N-Butyl-3-methoxy-4-(7H-purin-8-yl)benzene-1-sulfonamide

실험 절차

Prepared analogously to Example 51 from n-butylamine and 8-(2'-methoxy-4'-chlorosulfonyl-phenyl)-purine hydrochloride. After the reaction finished, the aqueous phase wsa extracted with ethyl acetate. The residue remaining after the ethyl acetate phases were evaporated was digested with ethanol, subjected to suction filtration, and washed with water.

후처리

  1. extractionthe aqueous phase wsa extracted with ethyl acetate
  2. customwere evaporated
  3. filtrationsubjected to suction filtration
  4. washwashed with water

출처 및 근거

ORD 기록
ord-26e7ee9c5273417092af8e873a3bc02f
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04582837

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