Methyl 4-chloroacetoacetate → HCID 178494252, 화합물

HRID 1380848노트

반응식

HRID 1380848 반응식
Cl.[CH3:2][O:3][C:4](=[NH:6])[NH2:5].[Cl:7][CH2:8][C:9](=O)[CH2:10][C:11](OC)=[O:12]>>[Cl:7][CH2:8][C:9]1[CH:10]=[C:11]([OH:12])[N:5]=[C:4]([O:3][CH3:2])[N:6]=1

참가 물질

3

반응물 2

HCID 36240Methyl 4-chloroacetoacetateHCID 3083899Carbamimidic acid, methyl ester, hydrochloride (1:1)

생성물 1

HCID 178494252HCID 178494252, 화합물

실험 절차

Analogously to the process described in Example 113, O-methylisourea hydrochloride or hydrosulphate is reacted with methyl 4-chloroacetoacetate in order to produce 4-chloromethyl-6-hydroxy-2-methoxy-pyrimidine, m.p. 154°-155° C., which is required as the starting material in Examples 68, 69 and 77.

출처 및 근거

ORD 기록
ord-a4028b126a79412ba20df64ffc2d5794
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04584295

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