Acrylamide → 3-(Piperidin-1-yl)propanamide

HRID 1380904

반응식

HRID 1380904 반응식
C(S)(=N)N.[NH:5]1[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1.[C:11]([NH2:15])(=[O:14])[CH:12]=[CH2:13]>CCO>[N:5]1([CH2:13][CH2:12][C:11]([NH2:15])=[O:14])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1

참가 물질

5

반응물 3

HCID 6579AcrylamideHCID 8082PiperidineHCID 178513445HCID 178513445, 화합물

생성물 1

HCID 5667843-(Piperidin-1-yl)propanamide수율 75%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Carbamimidothioic acid, N'-cyano-N-[3-[4-(diphenylmethylene)-1-piperidinyl]-propyl]-, methyl ester. A solution of piperidine, 4-(diphenylmethylene) (0.10 mole) and acrylamide (8.95 g, 0.062 mole) in EtOH (50 ml) was refluxed overnight. This reaction mixture was filtered and concentrated. The resulting while solid residue was dissolved in CHCl3, washed with H2O (3×150 ml), dried (Na2SO4) and the solvent removed to give thick yellow oil. Crystallization from CH2Cl2 -i-Pr2O afforded 29.01 g (75%) of 1-piperidinepropanamide, 4-(diphenylmethylene)-; mp 105°-7° C.

후처리

  1. filtrationThis reaction mixture was filtered
  2. concentrationconcentrated
  3. dissolutionThe resulting while solid residue was dissolved in CHCl3
  4. washwashed with H2O (3×150 ml)
  5. dry with materialdried (Na2SO4)
  6. customthe solvent removed
  7. customto give thick yellow oil
  8. customCrystallization from CH2Cl2 -i-Pr2O

출처 및 근거

ORD 기록
ord-1789272e3d394ccf8937f1b06bce883b
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04584301

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