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Water → 2-(4-Chlorophenoxy)-1-(4-chlorophenyl)-2-methylpropan-1-one

HRID 1380923
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HRID 1380923 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].O.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]([C:25](Br)([CH3:27])[CH3:26])=[O:24])=[CH:19][CH:18]=1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:25]([C:23]([C:20]2[CH:19]=[CH:18][C:17]([Cl:16])=[CH:22][CH:21]=2)=[O:24])([CH3:27])[CH3:26])=[CH:4][CH:3]=1
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참가 물질

6

반응물 4

HCID 962Water2회HCID 46844-ChlorophenolHCID 11430Potassium CarbonateHCID 112999732-Bromo-1-(4-chlorophenyl)-2-methylpropan-1-one

생성물 1

HCID 198424902-(4-Chlorophenoxy)-1-(4-chlorophenyl)-2-methylpropan-1-one수율 85%

시약·촉매·용매 1

HCID 1140
Toluene
용매
2회

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온도
40 °C

실험 절차

52 g (0.3982 mol) of p-chlorophenol and 55 g (0.3982 mol) of potassium carbonate in 400 ml of toluene are heated under reflux for 2 hours, using a water separator. The mixture is cooled to 40° C. and a solution of 2-bromo-prop-2-yl 4-chlorophenyl ketone in 170 ml of toluene is added dropwise. This reaction mixture is subsequently stirred at 100° C. for 5 hours and is then cooled, water is added and the organic phase is separated off. This phase is washed with dilute sodium hydroxide solution and water, dried over sodium sulphate and concentrated. 87 g (85% of theory) of crude 4-chlorophenyl 2-(p-chlorophenoxy)-prop-2-yl ketone are obtained and are further reacted directly. ##STR160##

후처리

  1. temperatureunder reflux for 2 hours
  2. temperatureis then cooled
  3. customthe organic phase is separated off
  4. washThis phase is washed with dilute sodium hydroxide solution and water
  5. dry with materialdried over sodium sulphate
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-fcef4b0198d04eddb2296940c5f41692
출처 데이터셋
uspto-grants-1986_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04584308

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