Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1380927생성일: 2026년 10월 26일
Acetyl chloride → 4-Cyclopropyl-1,8-diethyl-2,3,4,9-tetrahydro-1H-carbazole-1-acetic Acid Methyl Ester
https://huagongshe.com/reaction/1380927
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetyl chloride | HCID 6367 | — |
| 반응물 | (2-Ethylphenyl)hydrazine | HCID 2733210 | — |
| 반응물 | 2-Carbomethoxymethyl-2-ethyl-5-cyclopropylcyclohexanone | HCID 13649242 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4-Cyclopropyl-1,8-diethyl-2,3,4,9-tetrahydro-1H-carbazole-1-acetic Acid Methyl Ester | HCID 13649243 | 34% |
반응 단계
The mixture of diastereomeric ketones (40 mmol, 9.52 g) prepared in Step (d) and 2-ethylphenylhydrazine (40 mmol, 5.45 g) were heated at reflux in 172 ml of MeOH for 60 hours, cooled to 0° C. and treated with 80 mmol (6.28 g, 5.7 ml) of AcCl. The reaction was refluxed an additional 45 minutes followed by removal of solvent in vacuo. Flash chromatography afforded 4.58 g (13.5 mmol, 34%) of orange oil containing a mixture of diastereomers.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US04584312 |
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| 출처 데이터셋 | uspto-grants-1986_04 |
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| ORD ID | ord-78203b2344ab48beb07987c856158a23 |
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| 출처 메모 | uspto-grants-1986_04 |
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