Ethanol → Ethyl 3-[4-(trifluoromethyl)phenyl]prop-2-enoate

반응식

[F:1][C:2]([F:15])([F:14])[C:3]1[CH:13]=[CH:12][C:6]([CH:7]=[CH:8][C:9]([OH:11])=[O:10])=[CH:5][CH:4]=1.S(=O)(=O)(O)O.[CH2:21](O)[CH3:22]>>[CH2:21]([O:10][C:9](=[O:11])[CH:8]=[CH:7][C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:14])([F:15])[F:1])=[CH:13][CH:12]=1)[CH3:22]

참가 물질

반응물 3

HCID 702Ethanol

HCID 1118Sulfuric Acid

HCID 749403-[4-(Trifluoromethyl)phenyl]prop-2-enoic acid

생성물 1

HCID 53662772Ethyl 3-[4-(trifluoromethyl)phenyl]prop-2-enoate

실험 절차

A suspension of 300 g of 4-trifluoromethylcinnamic acid (J. Org. Chem. 43:980 (1978)) and 25 ml of concentrated sulfuric acid in 1.7 liters of ethanol is heated to reflux for 24 hours. The solution is concentrated, cooled, and filtered to give as a white solid, 4-trifluoromethylcinnamic acid ethyl ester, mp 40°-41° C.