1-benzyl-4-methoxycarbonyl-4-(N-phenylmethoxyacetamido)piperidine → 4-methoxycarbonyl-4-(N-phenylmethoxyacetamido)piperidine

HRID 1380956노트

반응식

HRID 1380956 반응식
C([N:8]1[CH2:13][CH2:12][C:11]([C:26]([O:28][CH3:29])=[O:27])([N:14]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:15](=[O:17])[CH3:16])[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>[Pd].C(O)(=O)C>[CH3:29][O:28][C:26]([C:11]1([N:14]([O:18][CH2:19][C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:15](=[O:17])[CH3:16])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)=[O:27]

참가 물질

5

반응물 2

HCID 233248381-benzyl-4-methoxycarbonyl-4-(N-phenylmethoxyacetamido)piperidineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 233248214-methoxycarbonyl-4-(N-phenylmethoxyacetamido)piperidine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 176Acetic Acid용매

실험 절차

A mixture of 12.45 g of 1-benzyl-4-methoxycarbonyl-4-(N-phenylmethoxyacetamido)piperidine and 250 ml of acetic acid is hydrogenated at room temperature and pressure with 1.5 g of 10% palladium-on-charcoal catalyst. After the calculated amount of hydrogen is taken up, the catalyst is filtered off. The acetic acid is flash evaporated, the residue is dissolved in toulene and stirred with 10 g of anhydrous sodium carbonate. The solid is filtered and the filtrate is flash evaporated to obtain 4-methoxycarbonyl-4-(N-phenylmethoxyacetamido)piperidine.

후처리

  1. customis hydrogenated at room temperature
  2. filtrationthe catalyst is filtered off
  3. customevaporated
  4. dissolutionthe residue is dissolved in toulene
  5. filtrationThe solid is filtered
  6. customevaporated

출처 및 근거

ORD 기록
ord-cbccb428274b419395cd1469a0960944
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04584303

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