Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Fuming sulfuric acid → Sulfuric Acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Fuming sulfuric acid | HCID 24681 | — |
| 반응물 | 7-Chloro-2,3-dihydro-4-quinolone | HCID 88974 | — |
| 반응물 | Trifluoroborane Hydrofluoride | HCID 9855450 | — |
| 반응물 | 3-((3-Chlorophenyl)amino)propanoic acid | HCID 12470919 | — |
| 생성물 | Sulfuric Acid | HCID 1118 | — |
| 생성물 | Boron trifluoride | HCID 6356 | — |
| 생성물 | Hydrofluoric Acid | HCID 14917 | — |
반응 단계
It should, however, be noted that, in the particular case of the cyclisation of 3-(m-chloroanilino)propionic acid by polyphosphoric acid, a mixture of substantially equal quantities of 5-chloro- and 7-chloro-1,2,3,4-tetrahydro-4-quinolinone is obtained. The selectivity for 7-chloro-1,2,3,4-tetrahydro-4-quinolinone is significantly improved if an oleum or a hydrofluoric acid/boron trifluoride mixture is used as cyclisation agent, but the industrial use of these processes encounters difficulties which result either from the handling of large quantities of sulphuric acid or from the utilisation of a mixture of anhydrous hydrofluoric acid and boron trifluoride.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04585867 |
| 출처 데이터셋 | uspto-grants-1986_04 |
| ORD ID | ord-ff019c51e3c24b779fec4d063a1af4d9 |
| 출처 메모 | uspto-grants-1986_04 |