Water → 7-Chloro-1,2-benzisothiazole-1,1-dioxide

HRID 1381471노트

반응식

HRID 1381471 반응식
C([N:5]1[CH:9](O)[C:8]2[CH:11]=[CH:12][CH:13]=[C:14]([Cl:15])[C:7]=2[S:6]1(=[O:17])=[O:16])(C)(C)C.CC1C=CC(S(O)(=O)=O)=CC=1.O>C1C=CC=CC=1>[Cl:15][C:14]1[C:7]2[S:6](=[O:17])(=[O:16])[N:5]=[CH:9][C:8]=2[CH:11]=[CH:12][CH:13]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 6101p-Toluenesulfonic acidHCID 13686308HCID 13686308, 화합물

생성물 1

HCID 136863097-Chloro-1,2-benzisothiazole-1,1-dioxide수율 69.9%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

A solution of 37 g of 2-t-butyl-3-hydroxy-7-chloro-2,3-dihydro-1,2-benzisothiazole-1,1-dioxide and 0.2 g of tosic acid in 370 mls of benzene was refluxed through a Dean-Stark water separator for 16 hours, cooled in ice and filtered to give 18.9 g of the title compound as colorless crystals, m.p. 162°-164° C.

후처리

  1. temperaturecooled in ice
  2. filtrationfiltered

출처 및 근거

ORD 기록
ord-16ed9fb93ae14a9383d7233f69d59638
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04802911

반응 노트

불러오는 중…