Water → beta-[(2-Hydroxy-1-methylethyl)amino]-alpha-phenylbenzeneethanol

HRID 1381523노트

반응식

HRID 1381523 반응식
[CH:1]1[CH:2]=[CH:3][C:4]([C@H:7]2[O:9][C@@H:8]2[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)=[CH:5][CH:6]=1.[NH2:16][CH:17]([CH3:20])[CH2:18][OH:19].O>CO>[OH:19][CH2:18][CH:17]([NH:16][CH:7]([C:4]1[CH:3]=[CH:2][CH:1]=[CH:6][CH:5]=1)[CH:8]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[OH:9])[CH3:20]

참가 물질

5

반응물 3

HCID 962WaterHCID 51262-AminopropanolHCID 185583(R,R)-Stilbene oxide

생성물 1

HCID 14391210beta-[(2-Hydroxy-1-methylethyl)amino]-alpha-phenylbenzeneethanol수율 79%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of trans-stilbene oxide (3.93 g, 0.020 mole) and 2-amino-1-propanol (4.51 g, 0.060 mole) was heated on a steam bath for 18 hours. The reaction mixture was dissolved in methanol (20 ml) and the solution poured into water (200 ml). The viscous oil which separated from the solution crystallized on standing. The solid was collected to obtain 4.29 g (79%) of material which was recrystallized from toluene to give 3.36 g of a white solid. The solid was dried in vacuo for 2 hours, m.p. 104°-105° C.

후처리

  1. temperaturewas heated on a steam bath for 18 hours
  2. customThe viscous oil which separated from the solution
  3. customcrystallized
  4. customThe solid was collected

출처 및 근거

ORD 기록
ord-c0fab2521406409ca20e95d161d42351
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04803200

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