4-Toluenesulfonyl chloride → N,N-dimethyl-N'-(2,3-dihydrobenzofuran-2-ylmethyl)-1,3-propanediamine

HRID 1381537

반응식

HRID 1381537 반응식
[CH2:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:10])[CH:2]=[CH2:3].O1C2C=CC=CC=2CC1CO.S(C1C=CC(C)=CC=1)([O-])(=O)=O.C1(C)C=CC(S(Cl)(=O)=O)=CC=1.[CH3:44][N:45]([CH3:50])[CH2:46][CH2:47][CH2:48][NH2:49]>>[CH3:44][N:45]([CH3:50])[CH2:46][CH2:47][CH2:48][NH:49][CH2:3][CH:2]1[CH2:1][C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[O:10]1

참가 물질

6

반응물 5

HCID 73974-Toluenesulfonyl chlorideHCID 7993N,N-Dimethyl-1,3-propanediamineHCID 156242-AllylphenolHCID 85570p-Toluenesulfonate2회HCID 2795428(2,3-Dihydro-1-benzofuran-2-yl)methanol

생성물 1

HCID 14099475N,N-dimethyl-N'-(2,3-dihydrobenzofuran-2-ylmethyl)-1,3-propanediamine

실험 절차

The starting diamine of formula II can be prepared according to known processes; for example starting from 2-allylphenol, which is then converted to 2,3-dihydrobenzofuran-2-yl-methanol by the action of a peracid and subsequently to the tosylate by the action of para-toluene-sulphonyl chloride, the said tosylate then being reacted with 3-(dimethylamino)-propylamine to give N,N-dimethyl-N'-(2,3-dihydro-benzofuran-2-ylmethyl)-1,3-propanediamine.

출처 및 근거

ORD 기록
ord-a211fe6f97894c4d861f90298e5ffa0a
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04803219

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