Acetic Acid → HCID 54343451, 화합물

HRID 1381626노트

반응식

HRID 1381626 반응식
[CH3:1][C:2]1[C:3]([CH3:23])=[CH:4][C:5]2[O:9][C:8]([CH:10]=[CH:11][C:12]3[CH:21]=[CH:20][C:15]([C:16]([O:18]C)=[O:17])=[CH:14][CH:13]=3)=[N:7][C:6]=2[CH:22]=1.C(O)(=O)C.S(=O)(=O)(O)O>O>[CH3:1][C:2]1[C:3]([CH3:23])=[CH:4][C:5]2[O:9][C:8]([CH:10]=[CH:11][C:12]3[CH:21]=[CH:20][C:15]([C:16]([OH:18])=[O:17])=[CH:14][CH:13]=3)=[N:7][C:6]=2[CH:22]=1

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 1118Sulfuric AcidHCID 102316Benzoic acid, 4-[2-(5,6-dimethyl-2-benzoxazolyl)ethenyl]-, methyl ester

생성물 1

HCID 54343451HCID 54343451, 화합물수율 89.8%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A mixture of 3.0 g methyl 4-[(5,6-dimethyl-2-benzoxazolyl)vinyl]benzoate, 25 mL of acetic acid, 9.0 mL of concentrated sulfuric acid, and 7 mL of water is stirred and refluxed for three hours. The mixture is cooled and added to water. The product is collected by filtration, washed with water and air dried. The crude product is recrystallized from N,N-dimethylformamide to give 2.57 g of 4-[2-(5,6-dimethyl-2-benzoxazolyl)vinyl]benzoic acid, which melts at >300° C.

후처리

  1. temperaturerefluxed for three hours
  2. temperatureThe mixture is cooled
  3. filtrationThe product is collected by filtration
  4. washwashed with water and air
  5. customdried
  6. customThe crude product is recrystallized from N,N-dimethylformamide

출처 및 근거

ORD 기록
ord-9ce406e63caa46fe8fd5db9efff1d59a
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04803241

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