Ethyl 2,4-dinitro-5-fluorophenoxyacetate → 7-Fluoro-6-amino-2H-1,4-benzoxazin-3(4H)-one

HRID 1381643노트

반응식

HRID 1381643 반응식
[N+:1]([C:4]1[CH:16]=[C:15]([N+:17]([O-])=O)[C:14]([F:20])=[CH:13][C:5]=1[O:6][CH2:7][C:8](OCC)=[O:9])([O-])=O.[H][H]>C(O)C.[C].[Pd]>[F:20][C:14]1[C:15]([NH2:17])=[CH:16][C:4]2[NH:1][C:8](=[O:9])[CH2:7][O:6][C:5]=2[CH:13]=1

참가 물질

5

반응물 2

HCID 14423667Ethyl 2,4-dinitro-5-fluorophenoxyacetateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 103133897-Fluoro-6-amino-2H-1,4-benzoxazin-3(4H)-one수율 82.8%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매

실험 절차

A suspension of ethyl 2,4-dinitro-5-fluorophenoxyacetate (1.3 g) and 5% palladium-carbon (0.35 g) in ethanol (30 ml) was subjected to catalytic reduction at room temperature under an ordinary pressure until 600 ml of hydrogen was absorbed. The reaction mixture was filtered, and the filtrate was concentrated to give 7-fluoro-6-amino-2H-1,4-benzoxazin-3(4H)-one (0.68 g; yield, 82.8%).

후처리

  1. customwas absorbed
  2. filtrationThe reaction mixture was filtered
  3. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-92e17dc7626b4ac49c68a069184d8e04
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04803270

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