Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1381669생성일: 2026년 10월 26일
Olprinone → 5-(3-Bromoimidazo[1,2-a]pyridin-6-yl)-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile hydrobromide
https://huagongshe.com/reaction/1381669
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Olprinone | HCID 4593 | — |
| 반응물 | Bromine | HCID 24408 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 5-(3-Bromoimidazo[1,2-a]pyridin-6-yl)-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile hydrobromide | HCID 21276428 | 155.9% |
반응 단계
In 10 ml of acetic acid was dissolved 0.3 g of 1,2-dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile. To the solution 0.2 g of bromine was added and the mixture was warmed to 30° C. After cooling, precipitated white crystals were taken by filtration. After washing with ether, the crystals were recrystallized from methanol to obtain 0.4 g of 5-(3-bromoimidazo[1,2-a]pyridin-6-yl)-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile hydrobromide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US04803276 |
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| 출처 데이터셋 | uspto-grants-1989_02 |
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| ORD ID | ord-3d7cb9eccec548fe90ce57db5ff6eff6 |
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| 출처 메모 | uspto-grants-1989_02 |
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