Sulfuric Acid → HCID 14372231, 화합물

HRID 1381717

반응식

HRID 1381717 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[CH:4][C:3]=1[C:11]([OH:13])=[O:12].OS(O)(=O)=O>C(O)(C)C.OS(O)(=O)=O>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([O:10][CH:2]([CH3:7])[CH3:3])=[O:9])[CH:5]=[CH:4][C:3]=1[C:11]([O:13][CH:5]([CH3:6])[CH3:4])=[O:12]

참가 물질

5

반응물 2

HCID 1118Sulfuric AcidHCID 747852-Chloroterephthalic acid

생성물 1

HCID 14372231HCID 14372231, 화합물

시약·촉매·용매 2

HCID 1118Sulfuric Acid촉매HCID 3776Isopropanol용매

실험 절차

To 2.0 g of product from Example 1 suspended in 25 ml of isopropyl alcohol was added 0.3 ml of conc. H2SO4 and the reaction mixture heated at reflux for about 18 hours. Conc. H2SO4 (5 drops) was then added and heating continued for an additional 24 hours. The reaction mixture was cooled to room temperature. The solvent was removed and the residue treated with 50 ml of saturated sodium bicarbonate solution and 50 ml of ethyl acetate. The organic phase was dried over sodium sulfate and the solvent removed under nitrogen. Dissolution in pentane followed by removal of the solvent gave the above product.

후처리

  1. temperaturethe reaction mixture heated
  2. temperatureat reflux for about 18 hours
  3. temperatureheating
  4. customThe solvent was removed
  5. additionthe residue treated with 50 ml of saturated sodium bicarbonate solution and 50 ml of ethyl acetate
  6. dry with materialThe organic phase was dried over sodium sulfate
  7. customthe solvent removed under nitrogen
  8. dissolutionDissolution in pentane
  9. customfollowed by removal of the solvent
  10. customgave the above product

출처 및 근거

ORD 기록
ord-baea4a33f56042d1beeb86ba3e79f8b5
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04803294

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