Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 13818생성일: 2026년 10월 24일
Acetoxyacetyl chloride → 2-{[3-Acetyl-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl]amino}-2-oxoethyl acetate
https://huagongshe.com/ko/reaction/13818
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetoxyacetyl chloride | HCID 26297 | — |
| 반응물 | 3-acetyl-4-amino-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-methyl-1,8-naphthyridin-2(1H)-one | HCID 11260007 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 2-{[3-Acetyl-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl]amino}-2-oxoethyl acetate | HCID 11365162 | — |
반응 단계
To the product of Example 2 (120 mg) in acetonitrile (2 mL) was added acetoxyacetyl chloride (0.2 mL). The reaction was heated to 90° C. in a CEM microwave reactor for a total of 34 minutes. The reaction was diluted with EtOAc and was washed with saturated aqueous NaHCO3 solution. The concentrated residue was purified by flash chromatography on silica gel gradient eluted with 0-60% EtOAc in hexane affording the title compound. HPLC/MS: 572.1 (M+1), 574.1 (M+3); Rt=4.06 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07728141B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_06 |
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| ORD ID | ord-6bbe050a73ec42f596a556812d626ba7 |
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| 출처 메모 | uspto-grants-2010_06 |
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