2-Anthracenemethanol → 2-anthracenecarbaldehyde

HRID 1381804노트

반응식

HRID 1381804 반응식
[CH:1]1[C:14]2[C:5](=[CH:6][C:7]3[C:12]([CH:13]=2)=[CH:11][CH:10]=[CH:9][CH:8]=3)[CH:4]=[CH:3][C:2]=1[CH2:15][OH:16].[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>C(Cl)Cl>[CH:1]1[C:14]2[C:5](=[CH:6][C:7]3[C:12]([CH:13]=2)=[CH:11][CH:10]=[CH:9][CH:8]=3)[CH:4]=[CH:3][C:2]=1[CH:15]=[O:16]

참가 물질

4

반응물 2

HCID 12014782-AnthracenemethanolHCID 178418287HCID 178418287, 화합물

생성물 1

HCID 17123542-anthracenecarbaldehyde수율 51%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2-Anthracenylmethanol (46A, 1.0 g, 0.0048 mol) in CH2Cl2 (700 mL) was treated with pyridinium chlorochromate (PCC) (Aldrich, 21.56 g, 0.1 mol) and heated for 4 h. The reaction was cooled and filtered through a plug of SiO2 (500 g) using CH2Cl2 as the eluting solvent. After removal of the solvent the crude material was chromatographed on SiO2 with PhCH3 as the eluting solvent to afford 0.5 g (51%) of 2-anthracenecarbaldehyde mp 201°-202.5° (lit mp 202°-203°, P. H. Gore, J. Chem. Soc. 1616 (1959)), (C, H).

후처리

  1. temperatureheated for 4 h
  2. temperatureThe reaction was cooled
  3. filtrationfiltered through a plug of SiO2 (500 g)
  4. customAfter removal of the solvent the crude material
  5. customwas chromatographed on SiO2 with PhCH3 as the eluting solvent

출처 및 근거

ORD 기록
ord-90eee7970e444c2380bb5eff494f78f6
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04803221

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