m-Chloroperbenzoic acid → 2-methoxy-5-methyl-2H-1,4-thiazin-3(4H)-one

HRID 1381899노트

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HRID 1381899 반응식
ClC1C=CC=C([C:8](OO)=[O:9])C=1.[CH3:12][C:13]1[NH:14][C:15](=[O:19])[CH2:16][S:17][CH:18]=1>CO>[CH3:8][O:9][CH:16]1[C:15](=[O:19])[NH:14][C:13]([CH3:12])=[CH:18][S:17]1

참가 물질

4

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 2900175-Methyl-2h-1,4-thiazin-3(4h)-one

생성물 1

HCID 143697982-methoxy-5-methyl-2H-1,4-thiazin-3(4H)-one수율 61.1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

m-Chloroperbenzoic acid (28.8 g) was added dropwise to a stirred solution of 5-methyl-2H-1,4-thiazin-3(4H)-one (15 g) in methanol (300 ml) under ice-cooling and the mixture was stirred at room temperature for 1 day. After the mixture was evaporated to dryness, the residue was extracted with ethyl acetate, washed with saturated sodium bicarbonate aqueous solution and dried over anhydrous magnesium sulfate. The solvent was evaporated to dryness to give 2-methoxy-5-methyl-2H-1,4-thiazin-3(4H)-one (11.3 g, yield 61%) as pale yellow powder.

후처리

  1. temperaturecooling
  2. customAfter the mixture was evaporated to dryness
  3. extractionthe residue was extracted with ethyl acetate
  4. washwashed with saturated sodium bicarbonate aqueous solution
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customThe solvent was evaporated to dryness

출처 및 근거

ORD 기록
ord-5a9e8f87d0e84e33951412dd4fb6b6b7
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04804668

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