Methyl 4-(1H-imidazol-1-yl)benzoate → N-[2-[Bis-(phenylmethyl)amino]ethyl]-4-(1H-imidazol-1-yl)-benzamide hemihydrate

HRID 1381910

반응식

HRID 1381910 반응식
C[O:2][C:3](=[O:15])[C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)=[CH:6][CH:5]=1.[CH2:16]([N:23]([CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[CH2:24][CH2:25][NH2:26])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[OH2:2].[C:28]1([CH2:27][N:23]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:24][CH2:25][NH:26][C:3](=[O:15])[C:4]2[CH:5]=[CH:6][C:7]([N:10]3[CH:14]=[CH:13][N:12]=[CH:11]3)=[CH:8][CH:9]=2)[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1.[C:17]1([CH2:16][N:23]([CH2:24][CH2:25][NH:26][C:3](=[O:15])[C:4]2[CH:5]=[CH:6][C:7]([N:10]3[CH:14]=[CH:13][N:12]=[CH:11]3)=[CH:8][CH:9]=2)[CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

참가 물질

3

반응물 2

HCID 2766374Methyl 4-(1H-imidazol-1-yl)benzoateHCID 6394114N1,N1-Dibenzylethane-1,2-diamine

생성물 1

HCID 67833593N-[2-[Bis-(phenylmethyl)amino]ethyl]-4-(1H-imidazol-1-yl)-benzamide hemihydrate

실험 절차

Heat 4.23 g (21.0 mmol) of 4-(1H-imidazol-1-yl)benzoic acid methyl ester and 5.00 g (21.0 mmol) of N,N-dibenzylethylenediamine in 10 mL of xylenes at reflux for about 48 hr. Cool the solution to room temperature. Filter to obtain crystals of the title compound.

후처리

  1. temperatureat reflux for about 48 hr
  2. filtrationFilter

출처 및 근거

ORD 기록
ord-c768e08e13ee4479b9ccd4c63185e2fa
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04804662

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