Ethanol → 1-Benzyl-1-methyl-3-nitroguanidine

HRID 1382029노트

반응식

HRID 1382029 반응식
CNC[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH3:10][N:11](N=O)/[C:12](/[NH2:17])=[N:13]/[N+:14]([O-:16])=[O:15].[CH2:20](O)C>>[CH2:10]([N:11]([CH3:20])[C:12]([NH:13][N+:14]([O-:16])=[O:15])=[NH:17])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

4

반응물 3

HCID 702EthanolHCID 7669N-MethylbenzylamineHCID 95620601-Methyl-2-nitro-1-nitrosoguanidine

생성물 1

HCID 1356162101-Benzyl-1-methyl-3-nitroguanidine

실험 절차

N-Methylbenzylamine (9.89 g, 0.082 mol) is added dropwise to a suspension of MNNG (10.0 g, 0.068 mol) in aqueous ethanol (1:1 ethanol:water, v/v) at 25° C. A gradual exotherm to 44° C. occurs over the next 15 minutes. After stirring for 42 hours at ambient temperature, the white slurry is filtered. The resultant white solid (7.13 g) is recrystallized from hexanes:ethanol to afford pure product (white crystals, 6.06 g, 43.0%, melting point 103° C.-107° C.).

후처리

  1. customto 44° C.
  2. customoccurs over the next 15 minutes
  3. filtrationthe white slurry is filtered
  4. customThe resultant white solid (7.13 g) is recrystallized from hexanes
  5. customethanol to afford pure product (white crystals, 6.06 g, 43.0%, melting point 103° C.-107° C.)

출처 및 근거

ORD 기록
ord-b433fc0321064dea912f01027b16b4d7
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04804780

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