Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → Leucinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | N-benzoyl-L-alanine | HCID 709778 | — |
| 반응물 | HCID 131712768 | HCID 131712768 | — |
| 반응물 | Bz-Ala-Leu-OH | HCID 131712769 | — |
| 용매 | Potassium Chloride | HCID 4873 | — |
| 생성물 | Leucinamide | HCID 69640 | — |
| 생성물 | HCID 131712768 | HCID 131712768 | — |
반응 단계
To a solution of 2 ml 15 mM Bz-Ala-Leu-NH2 in 0.1M KCl-1 mM EDTA, pH 9.7, 25° C. and 10% dimethyl formamide was added 2 mg CPD-Y. The reaction course as shown on FIG. 5 was followed by HPLC as described in example 1. It is seen that Bz-Ala-Leu-NH2 after 20 minutes was completely converted to about 68% Bz-Ala-Leu-OH and 32% Bz-Ala-OH. Amino acid analysis on the reaction mixture showed that the Bz-Ala-OH was mainly formed by cleavage of Leu-NH2 from Bz-Ala-Leu-NH2.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04806473 |
| 출처 데이터셋 | uspto-grants-1989_02 |
| ORD ID | ord-f8fbcf70283b41f789cf889055b2fd52 |
| 출처 메모 | uspto-grants-1989_02 |