Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Nitrogen → 7-(4-Fluorophenyl)-5-oxo-5,7-dihydrofuro[3,4-b]pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Nitrogen | HCID 947 | — |
| 반응물 | 4-Fluorobenzaldehyde | HCID 68023 | — |
| 반응물 | 3-(Methoxycarbonyl)pyridine-2-carboxylic acid | HCID 290697 | — |
| 용매 | P-Cymene | HCID 7463 | — |
| 생성물 | 7-(4-Fluorophenyl)-5-oxo-5,7-dihydrofuro[3,4-b]pyridine | HCID 14581297 | — |
반응 단계
A suspension of 3-carbomethoxypicolinic acid (15.0 g, 0.083 mol) and 4-fluorobenzaldehyde (90.8 g. 0.732 mol) in 250 mL of p-cymene is heated to reflux under a stream of N2 for 16 hours. The mixture is then allowed to cool to room temperature, filtered and the filtrate distilled in vacuo to remove p-cymene. A solution of the crude residue in CH2Cl2 is chromatographed on silica gel (using Et2O-hexane (2:1) as the eluent). Recrystallization from hexane-EtOAc gives pure 7-(4-fluorophenyl)-5-oxo-5,7-dihydrofuro[3,4-b]pyridine. M.P. 116°-117.5° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04806535 |
| 출처 데이터셋 | uspto-grants-1989_02 |
| ORD ID | ord-d0750fe4bba1443fb6b24b7d1c769a09 |
| 출처 메모 | uspto-grants-1989_02 |