HCID 178471921, 화합물 → 3-cyclohexylcarbonyl-8-methoxy-4(1H)-quinolone

HRID 1382319노트

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HRID 1382319 반응식
[CH:1]1([C:7]([C:9](=[CH:15][NH:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[O:23][CH3:24])[C:10]([O:12]CC)=O)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>C1(OC2C=CC=CC=2)C=CC=CC=1>[CH:1]1([C:7]([C:9]2[C:10](=[O:12])[C:22]3[C:17](=[C:18]([O:23][CH3:24])[CH:19]=[CH:20][CH:21]=3)[NH:16][CH:15]=2)=[O:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

참가 물질

3

반응물 1

HCID 178471921HCID 178471921, 화합물

생성물 1

HCID 100167833-cyclohexylcarbonyl-8-methoxy-4(1H)-quinolone수율 35.2%

시약·촉매·용매 1

HCID 7583Diphenyl Ether용매

실험 절차

Ethyl 2-cyclohexylcarbonyl-3-(2-methoxyphenylamino)acrylate (20 g, 0.06 mol) was added in portions to boiling diphenyl ether (200 ml) and the mixture was heated under reflux for 1.5 hours. When cool, the mixture was diluted with petroleum ether and allowed to crystallise overnight to give 3-cyclohexylcarbonyl-8-methoxy-4(1H)-quinolone (6.0 g, 35.2%), m.p. 168°-70° C.

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 1.5 hours
  3. temperatureWhen cool
  4. customto crystallise overnight

출처 및 근거

ORD 기록
ord-0d22e12c6226428f87227f7bf6bda92e
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04806550

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