Ethyl Acetate → 3-Benzoyl-4-(2-methoxyphenylamino)-8-methoxyquinoline

HRID 1382325노트

반응식

HRID 1382325 반응식
C(C1C=NC2C(C=1Cl)=CC=CC=2OC)(=O)C1C=CC=CC=1.[C:22]([C:30]1[CH:31]=[N:32][C:33]2[C:38]([C:39]=1[NH:40][C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=1[O:47][CH3:48])=[CH:37][CH:36]=[CH:35][C:34]=2[O:49][CH3:50])(=[O:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.C(OCC)(=O)C>O1CCOCC1.COC1C(N)=CC=CC=1>[C:22]([C:30]1[CH:31]=[N:32][C:33]2[C:38]([C:39]=1[NH:40][C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=1[O:47][CH3:48])=[CH:37][CH:36]=[CH:35][C:34]=2[O:49][CH3:50])(=[O:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

참가 물질

5

반응물 2

HCID 8857Ethyl AcetateHCID 212745613-benzoyl-4-(2-methoxyphenylamino)-8-methoxyquinoline 3-Benzoyl-4-chloro-8-methoxyquinoline

생성물 1

HCID 212745583-Benzoyl-4-(2-methoxyphenylamino)-8-methoxyquinoline수율 61%

시약·촉매·용매 2

HCID 70002-Methoxyaniline용매HCID 312751,4-Dioxane용매

실험 절차

Preparation of 3-benzoyl-4-(2-methoxyphenylamino)-8-methoxyquinoline 3-Benzoyl-4-chloro-8-methoxyquinoline (2.8 g, 0.0094 mol) was heated under reflux in a mixture of 1,4-dioxan (50 ml) and o-anisidine (7 ml) for 1 hour. The solvent was evaporated and the residue was dissolved in dichloromethane, and washed with dilute hydrochloric acid, sodium hydrogen carbonate solution, water and brine. The organic solution was dried and evaporated to an oil which was chromatographed (silica gel, 1% methanol in dichloromethane) to give an oil which afforded yellow crystals of 3-benzoyl-4-(2-methoxyphenylamino)-8-methoxyquinoline (2.2 g, 61%) from ethyl acetate, m.p. 200°-202°.

후처리

  1. temperaturewas heated
  2. customThe solvent was evaporated
  3. dissolutionthe residue was dissolved in dichloromethane
  4. washwashed with dilute hydrochloric acid, sodium hydrogen carbonate solution, water and brine
  5. customThe organic solution was dried
  6. customevaporated to an oil which
  7. customwas chromatographed (silica gel, 1% methanol in dichloromethane)
  8. customto give an oil which

출처 및 근거

ORD 기록
ord-5f51b2bab7174239a6d55b6bda0fd751
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04806550

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