Sodium Azide → HCID 13292769, 화합물

HRID 1382626노트

반응식

HRID 1382626 반응식
Br[CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8](/[C:11](/[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[C:12](\[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)/[C:13]([F:16])([F:15])[F:14])=[CH:7][CH:6]=1.[N-:29]=[N+:30]=[N-:31].[Na+]>COCCO.O>[N:29]([CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8](/[C:11](/[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[C:12](\[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)/[C:13]([F:16])([F:15])[F:14])=[CH:7][CH:6]=1)=[N+:30]=[N-:31]

참가 물질

5

반응물 2

HCID 33557Sodium AzideHCID 13292770HCID 13292770, 화합물

생성물 1

HCID 13292769HCID 13292769, 화합물수율 82.2%

시약·촉매·용매 2

HCID 962Water용매HCID 80192-Methoxyethanol용매

실험 절차

9.83 g (22 mmoles) of (E)-1-[4-(2-bromoethoxy)-phenyl]-1,2-diphenyl-3,3,3-trifluoro-propene are dissolved in 100 ml of 2-methoxyethanol, a solution of 2.86 g (44 mmoles) of sodium azide in 10 ml of water is added, and the mixture is boiled for one hour. The reaction mixture is processed as described in Example 5, and the product is recrystallized twice from ethanol. 7.40 g (82%) of the aimed compound are obtained; m.p.: 73°-75° C.

후처리

  1. customthe product is recrystallized twice from ethanol

출처 및 근거

ORD 기록
ord-0e07e1eb2117425781e2138323f16132
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04806685

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