Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,2,2-Trifluoro-4'-methoxyacetophenone → 3,3,3-Trifluoro-1-(4-fluorophenyl)-2-(4-methoxyphenyl)-propene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,2,2-Trifluoro-4'-methoxyacetophenone | HCID 136555 | — |
| 반응물 | Sodium ethoxide | HCID 2723922 | — |
| 반응물 | (4-Fluorobenzyl)triphenylphosphonium chloride | HCID 2733554 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3,3,3-Trifluoro-1-(4-fluorophenyl)-2-(4-methoxyphenyl)-propene | HCID 57217065 | 87% |
반응 단계
4'-Methoxy-2,2,2-trifluoroacetophenone (R. Fuchs: J. Org. Chem. 22, 993-994 (1957)) is reacted with triphenyl(4-fluorobenzyl)-phosphonium chloride (see Example 18) in ethanol in the presence of sodium ethoxide. 3,3,3-Trifluoro-1-(4-fluorophenyl)-2-(4-methoxyphenyl)-propene is obtained with a yield of 87%; b.p.: 138°-142° C./0.5 mm Hg.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04806685 |
| 출처 데이터셋 | uspto-grants-1989_02 |
| ORD ID | ord-277848f9c6df4b28b5bbffe0f636b73f |
| 출처 메모 | uspto-grants-1989_02 |