Butyryl chloride → N-(6-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-3-cyanopyridin-2-yl)-N-methylbutyramide

HRID 13827

반응식

HRID 13827 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[C:13]([NH:15][CH3:16])[C:12]([C:17]#[N:18])=[CH:11][C:10]=1[C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=1.C[Mg+].[Br-].[C:29](Cl)(=[O:33])[CH2:30][CH2:31][CH3:32]>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[C:13]([N:15]([CH3:16])[C:29](=[O:33])[CH2:30][CH2:31][CH3:32])[C:12]([C:17]#[N:18])=[CH:11][C:10]=1[C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=1

참가 물질

4

반응물 3

HCID 8855Butyryl chlorideHCID 687190456-(2,4-Dichlorophenyl)-5-(4-chlorophenyl)-2-(methylamino)pyridine-3-carbonitrileHCID 178418689HCID 178418689, 화합물

생성물 1

HCID 68716563N-(6-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-3-cyanopyridin-2-yl)-N-methylbutyramide

실험 절차

The product of Step D Example 1 was reacted with MeMgBr followed by butyryl chloride using the procedure of EXAMPLE 42 Step A to afford the title compound.

출처 및 근거

ORD 기록
ord-7306c721767e42699fb70bc87308c008
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728141B2

연결된 노트

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