Sodium Azide → HCID 14304685, 화합물

HRID 1382718노트

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HRID 1382718 반응식
Cl[C:2]1[C:11]2[C:10](=[O:12])[N:9]([CH3:13])[C:8](=[O:14])[N:7]([CH3:15])[C:6]=2[N:5]=[CH:4][CH:3]=1.[N-:16]=[N+:17]=[N-:18].[Na+]>CN(C=O)C>[N:16]([C:2]1[C:11]2[C:10](=[O:12])[N:9]([CH3:13])[C:8](=[O:14])[N:7]([CH3:15])[C:6]=2[N:5]=[CH:4][CH:3]=1)=[N+:17]=[N-:18]

참가 물질

4

반응물 2

HCID 33557Sodium AzideHCID 143046845-Chloro-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

생성물 1

HCID 14304685HCID 14304685, 화합물수율 83.5%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

1.35 g of Compound 1 was dissolved in 10 ml of DMF and 0.52 g of 90% sodium azide was added thereto. The solution was stirred for 6 hr at room temperature and the solvent was distilled off under reduced pressure. After adding water, the resulting crystals were separated by filtration to give 1.16 g of 5-azido-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4-dione (Compound 3)

후처리

  1. distillationthe solvent was distilled off under reduced pressure
  2. additionAfter adding water
  3. customthe resulting crystals were separated by filtration

출처 및 근거

ORD 기록
ord-0fb6b87646764e8f8c9010c834ed242d
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04808587

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