Methane → 5-Amino-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

HRID 1382719노트

반응식

HRID 1382719 반응식
[N:1]([C:4]1[C:13]2[C:12](=[O:14])[N:11]([CH3:15])[C:10](=[O:16])[N:9]([CH3:17])[C:8]=2[N:7]=[CH:6][CH:5]=1)=[N+]=[N-].C>CO.[Pd]>[NH2:1][C:4]1[C:13]2[C:12](=[O:14])[N:11]([CH3:15])[C:10](=[O:16])[N:9]([CH3:17])[C:8]=2[N:7]=[CH:6][CH:5]=1

참가 물질

5

반응물 2

HCID 297MethaneHCID 14304685HCID 14304685, 화합물

생성물 1

HCID 132683465-Amino-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione수율 74%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

1.33 g of Compound 3 was dissolved in 400 ml of methanol and reduced in the presence of 300 mg of Pd-C. Activated charcoal powder was added, and the solution was heated and filtered. The filtrate was distilled under reduced pressure and ethanol added thereto. The resulting crude crystals were separated by filtration and recrystallized from ethanol to give 0.87 g of 5-amino-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4-dione (Compound 4).

후처리

  1. temperaturethe solution was heated
  2. filtrationfiltered
  3. distillationThe filtrate was distilled under reduced pressure and ethanol
  4. additionadded
  5. customThe resulting crude crystals were separated by filtration
  6. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-791360420a244b76ab2a826578cbd435
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04808587

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