1-Benzyl-3-acetamidopyrrolidine → 3-Acetamidopyrrolidine

HRID 1382755노트

반응식

HRID 1382755 반응식
[C:1]([NH:4][CH:5]1[CH2:9][CH2:8][N:7](CC2C=CC=CC=2)[CH2:6]1)(=[O:3])[CH3:2]>C(O)C.O.[C].[Pd]>[C:1]([NH:4][CH:5]1[CH2:9][CH2:8][NH:7][CH2:6]1)(=[O:3])[CH3:2]

참가 물질

5

반응물 1

HCID 41983391-Benzyl-3-acetamidopyrrolidine

생성물 1

HCID 5227153-Acetamidopyrrolidine수율 97.9%

시약·촉매·용매 3

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매HCID 962Water용매

실험 절차

To a solution of the above 3-acetylamino-1-benzylpyrrolidine (4.0 g) in ethanol (30 ml) was added 10% palladium-carbon (0.8 g) in water (1 ml). The mixture was shaken at room temperature for 22 hours under hydrogen pressure of 55 p.s.i. using Parr hydrogenator. The catalyst was filtered off and the solvent was distilled off under reduced pressure. The residue was dissolved in chloroform and dried over anydrous magnesium sulfate, followed by distilling off the solvent to give 3-acetylaminopyrrolidine (2.3 g) as oil.

후처리

  1. filtrationThe catalyst was filtered off
  2. distillationthe solvent was distilled off under reduced pressure
  3. dissolutionThe residue was dissolved in chloroform
  4. dry with materialdried over anydrous magnesium sulfate
  5. distillationby distilling off the solvent

출처 및 근거

ORD 기록
ord-fcdb9224cf8a452a811776cccaf6cad1
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04808584

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