1-(2-Hydroxyphenyl)-3-(1H-indol-4-yl)prop-2-en-1-one → 1-(2-Hydroxyphenyl)-3-(1H-indol-4-yl)propan-1-one

HRID 1382841노트

반응식

HRID 1382841 반응식
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:20])[CH:9]=[CH:10][C:11]1[CH:19]=[CH:18][CH:17]=[C:16]2[C:12]=1[CH:13]=[CH:14][NH:15]2>CO>[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:20])[CH2:9][CH2:10][C:11]1[CH:19]=[CH:18][CH:17]=[C:16]2[C:12]=1[CH:13]=[CH:14][NH:15]2

참가 물질

3

반응물 1

HCID 538459351-(2-Hydroxyphenyl)-3-(1H-indol-4-yl)prop-2-en-1-one

생성물 1

HCID 137856631-(2-Hydroxyphenyl)-3-(1H-indol-4-yl)propan-1-one수율 71%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 200 mg of the product of Step A in 10 ml of methanol was hydrogenated in the presence of palladized activated charcoal at room temperature until absorption ceased and was then filtered. The filtrate was evaporated to dryness and the residue was chromatographed over silica. Elution with a 6-3-1 cyclohexane-dichloromethane-triethylamine mixture yielded 143 mg of 1-(2-hydroxyphenyl)-3-(1H-indol-4-yl)-1-propanone melting at ≃143° C.

후처리

  1. customwas hydrogenated in the presence of palladized activated charcoal at room temperature until absorption
  2. filtrationwas then filtered
  3. customThe filtrate was evaporated to dryness
  4. customthe residue was chromatographed over silica
  5. washElution with a 6-3-1 cyclohexane-dichloromethane-triethylamine mixture

출처 및 근거

ORD 기록
ord-97648cff80d94f8283056914e3f47957
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04808609

반응 노트

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