Epichlorohydrin → HCID 57291601, 화합물

HRID 1382842노트

반응식

HRID 1382842 반응식
C(=O)([O-])[O-].[K+].[K+].[CH2:7]([CH:9]1[O:11][CH2:10]1)Cl.[OH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:19](=[O:31])[CH:20]=[CH:21][C:22]1[CH:30]=[CH:29][CH:28]=[C:27]2[C:23]=1[CH:24]=[CH:25][NH:26]2>CC(C)=O>[O:11]1[CH2:10][CH:9]1[CH2:7][O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:19](=[O:31])[CH:20]=[CH:21][C:22]1[CH:30]=[CH:29][CH:28]=[C:27]2[C:23]=1[CH:24]=[CH:25][NH:26]2

참가 물질

5

반응물 3

HCID 7835EpichlorohydrinHCID 11430Potassium CarbonateHCID 538459351-(2-Hydroxyphenyl)-3-(1H-indol-4-yl)prop-2-en-1-one

생성물 1

HCID 57291601HCID 57291601, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

First 3.46 g of potassium carbonate and then 10.5 ml of epichlorohydrin were added to a solution of 4 g of 1-[2-hydroxyphenyl]-3-(1H-indol-4-yl)-2-propen-1-one in 80 ml of acetone and the mixture was refluxed for 50 hours under an inert atmosphere and was filtered. The filtrate was evaporated to dryness and the residue was chromatographed over silica. Elution with a 95-5 dichloromethane-ethyl acetate mixture yielded 2.26 g of 1-[2-[(2-oxiranyl)-methoxy]-phenyl]-3-(1H-indol-4-yl)-2-propen-1-one.

후처리

  1. temperaturethe mixture was refluxed for 50 hours under an inert atmosphere
  2. filtrationwas filtered
  3. customThe filtrate was evaporated to dryness
  4. customthe residue was chromatographed over silica
  5. washElution with a 95-5 dichloromethane-ethyl acetate mixture

출처 및 근거

ORD 기록
ord-ed79a7725fa1420984771c47c737d67f
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04808609

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