Ammonia → Pyrido(4,3-d)pyrimidine-2,4(1H,3H)-dione, 1,3-dimethyl-

HRID 1382866노트

반응식

HRID 1382866 반응식
C([C:3]1[C:4](=[O:17])[N:5]([CH3:16])[C:6](=[O:15])[N:7]([CH3:14])[C:8]=1[CH:9]=[CH:10][N:11](C)[CH3:12])=O.N>C(O)C>[CH3:14][N:7]1[C:8]2[CH:9]=[CH:10][N:11]=[CH:12][C:3]=2[C:4](=[O:17])[N:5]([CH3:16])[C:6]1=[O:15]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 54245828HCID 54245828, 화합물

생성물 1

HCID 3086912Pyrido(4,3-d)pyrimidine-2,4(1H,3H)-dione, 1,3-dimethyl-수율 84.5%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

0.47 g of 5-formyl-1,3-dimethyl-6-(2-dimethylaminovinyl)uracil was dissolved in ethanol, and ammonia was added thereto. The solution was stirred for 30 min at room temperature. The precipitated crystals were separated from the solution by filtration and recrystallized from ethanol to give 0.32 g of 1,3-dimethylpyrido[4,3-d]pyrimidine-2,4-dione (Compound 1).

후처리

  1. customThe precipitated crystals were separated from the solution by filtration
  2. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-aae985345d584ab5a9e0c8b770495557
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04808618

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