m-Chloroperbenzoic acid → 2-Sulfamoylfuro[3,2-c]pyridine-5-oxide

HRID 1382986노트

반응식

HRID 1382986 반응식
[S:1]([C:5]1[O:13][C:12]2[CH:11]=[CH:10][N:9]=[CH:8][C:7]=2[CH:6]=1)(=[O:4])(=[O:3])[NH2:2].ClC1C=CC=C(C(OO)=[O:22])C=1>CO.C(OCC)(=O)C>[S:1]([C:5]1[O:13][C:12]2[CH:11]=[CH:10][N+:9]([O-:22])=[CH:8][C:7]=2[CH:6]=1)(=[O:3])(=[O:4])[NH2:2]

참가 물질

5

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 14372124Furo[3,2-c]pyridine-2-sulfonamide

생성물 1

HCID 143721302-Sulfamoylfuro[3,2-c]pyridine-5-oxide수율 83%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8857Ethyl Acetate용매2회

실험 절차

To a warm (40° C.) solution of 2-sulfamoylfuro[3,2-c]pyridine (2.68 g, 13.5 mmol) in methanol (30 ml) and ethyl acetate (10 ml) was added dropwise a solution of m-chloroperbenzoic acid (3.22 g, 15 mmol) in ethyl acetate (13 ml). The reaction mixture was stirred for 18 hours as product precipitated. The pure product was collected by filtration and crystallized from hot dimethyl sulfoxide by dilution with ethanol to give 2.4 g (83% yield), m.p. 247°-248° C.

후처리

  1. customprecipitated
  2. filtrationThe pure product was collected by filtration
  3. customcrystallized from hot dimethyl sulfoxide by dilution with ethanol
  4. customto give 2.4 g (83% yield), m.p. 247°-248° C.

출처 및 근거

ORD 기록
ord-9e64870d66ed47cd91d6e226ac95e6d4
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04808595

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