Hydrogen Peroxide → HCID 14372165, 화합물

HRID 1383009노트

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HRID 1383009 반응식
[S:1]([C:5]1[O:13][C:12]2[C:7](=[N:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=1)(=[O:4])(=[O:3])[NH2:2].[OH:14]O.O>C(O)(=O)C>[S:1]([C:5]1[O:13][C:12]2[C:7](=[N+:8]([O-:14])[CH:9]=[CH:10][CH:11]=2)[CH:6]=1)(=[O:3])(=[O:4])[NH2:2]

참가 물질

5

반응물 3

HCID 784Hydrogen PeroxideHCID 962WaterHCID 14372164Furo[3,2-b]pyridine-2-sulfonamide

생성물 1

HCID 14372165HCID 14372165, 화합물수율 63.5%

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
60 °C

실험 절차

To a suspension of 2-sulfamoylfuro[3,2-b]pyridine (647 mg, 3.27 mmol) in glacial acetic acid (8 mL) was added 30% hydrogen peroxide (0.6 mL). This suspension was warmed at 60° C. for four hours to give a clear solution. Upon cooling the reaction mixture and adding water the product crystallized out. This pure product (444 mg, 63.5% yield) was collected by filtration, washed with water, ethanol and diethyl ether, mp: 236°-237° C. (decomposition).

후처리

  1. customto give a clear solution
  2. temperatureUpon cooling the reaction mixture
  3. customcrystallized out

출처 및 근거

ORD 기록
ord-b71766f77c814328a55713543aafb0f8
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04808595

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