Z-N-Me-Val-N-Me-Tyr(3-tBu)-NH2 → N-Me-Val-N-Me-Tyr(3-tBu)-NH2

HRID 1383743노트

반응식

HRID 1383743 반응식
[C:1]([N:11](C)[C@H:12]([C:16]([N:18]([CH3:35])[C@H:19]([C:32]([NH2:34])=[O:33])[CH2:20][C:21]1[CH:26]=[CH:25][C:24]([OH:27])=[C:23]([C:28]([CH3:31])([CH3:30])[CH3:29])[CH:22]=1)=[O:17])[CH:13]([CH3:15])[CH3:14])(OCC1C=CC=CC=1)=O.[H][H]>CO.[OH-].[OH-].[Pd+2]>[NH:11]([CH3:1])[C@H:12]([C:16]([N:18]([CH3:35])[C@H:19]([C:32]([NH2:34])=[O:33])[CH2:20][C:21]1[CH:26]=[CH:25][C:24]([OH:27])=[C:23]([C:28]([CH3:31])([CH3:29])[CH3:30])[CH:22]=1)=[O:17])[CH:13]([CH3:15])[CH3:14]

참가 물질

5

반응물 2

HCID 131722751Z-N-Me-Val-N-Me-Tyr(3-tBu)-NH2HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 131722752N-Me-Val-N-Me-Tyr(3-tBu)-NH2

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 887Methanol용매

실험 절차

A mixture of Z-N-Me-Val-N-Me-Tyr(3-tBu)-NH2 (1.17 g) and 20% palladium hydroxide on carbon (0.24 g) in methanol (20 ml) was stirred at room temperature in a hydrogen atmosphere for 1 hour. The reaction mixture was filtered and washed with methanol. The solvent was distilled off under reduced pressure and the resulting residue was subjected to silica gel column chromatography (eluting solvent consisting of chloroform, methanol and aqueous ammonia at a ratio of 100:10:1) to give N-Me-Val-N-Me-Tyr(3-tBu)-NH2 in the amount of 609 mg (71%).

후처리

  1. filtrationThe reaction mixture was filtered
  2. washwashed with methanol
  3. distillationThe solvent was distilled off under reduced pressure
  4. washeluting solvent

출처 및 근거

ORD 기록
ord-08eb33597ad1421e851e417f5c042a51
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06255285B1

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