2-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)pyridine → 2-(1,4-Dioxaspiro[4.5]decan-8-yl)pyridine

HRID 1383777노트

반응식

HRID 1383777 반응식
[O:1]1[C:5]2([CH2:10][CH2:9][C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=3)=[CH:7][CH2:6]2)[O:4][CH2:3][CH2:2]1>C(OCC)(=O)C.[Pd]>[O:1]1[C:5]2([CH2:6][CH2:7][CH:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=3)[CH2:9][CH2:10]2)[O:4][CH2:3][CH2:2]1

참가 물질

4

반응물 1

HCID 211876502-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)pyridine

생성물 1

HCID 211876632-(1,4-Dioxaspiro[4.5]decan-8-yl)pyridine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 14.6 g (67.19 mmol) of 2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)pyridine in ethyl acetate (400 mL) was added 4.6 g of 10% palladium on carbon catalyst. The resulting suspension was then hydrogenated at ambient temperature and atmospheric pressure until all the starting material was consumed (10.5 hr). The reaction mixture was filtered through celite and the filtrate was concentrated to give the product as an oily solid.

후처리

  1. customwas then hydrogenated at ambient temperature
  2. customatmospheric pressure until all the starting material was consumed (10.5 hr)
  3. filtrationThe reaction mixture was filtered through celite
  4. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-365e63e73c6841f0a37f97f24c639be6
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06255315B1

반응 노트

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