2-Hydroxypropyl-Beta-Cyclodextrin → Codeine

HRID 1383797

반응식

HRID 1383797 반응식
[CH3:1][N:2]1[C@@H:18]2[CH2:19][C:7]3[CH:8]=[CH:9][C:10]([O:21][CH3:22])=[C:11]4[O:12][C@H:13]5[C@@H:14]([OH:20])[CH:15]=[CH:16][C@@H:17]2[C@:5]5([C:6]=34)[CH2:4][CH2:3]1.C([O-])(=O)CCCCCCCCCCC.CC(O)COC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@@H](O[C@H]5[C@H](O)[C@@H](O)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@@H](O[C@H]7[C@H](O)[C@@H](O)[C@@H](O[C@H]8[C@H](O)[C@@H](O)[C@@H](O[C@H]1[C@H](O)[C@H]2O)O[C@@H]8COCC(O)C)O[C@@H]7COCC(O)C)O[C@@H]6COCC(O)C)O[C@@H]5COCC(O)C)O[C@@H]4COCC(O)C)O[C@@H]3COCC(O)C>O>[CH3:1][N:2]1[C@@H:18]2[CH2:19][C:7]3[CH:8]=[CH:9][C:10]([O:21][CH3:22])=[C:11]4[O:12][C@H:13]5[C@@H:14]([OH:20])[CH:15]=[CH:16][C@@H:17]2[C@:5]5([C:6]=34)[CH2:4][CH2:3]1

참가 물질

4

반응물 2

HCID 140496892-Hydroxypropyl-Beta-Cyclodextrin2회HCID 86757113Codeine laurate2회

생성물 1

HCID 5284371Codeine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Codeine laurate and hydroxypropyl-beta-cyclodextrin were complexed by the kneading method. Codeine laurate (0.700 g) and hydroxypropyl-beta-cyclodextrin (2.045 g) were blended together. Water (5 ml was added and the mixture ground together in a mortar with a pestle to form a uniform paste. Grinding was continued for 30 minutes. The paste was then dried in a vacuum oven (40° C.; 0 bar) for 48 hours. The solid mass was broken up, passed through a 60 mesh screen and returned to the vacuum oven (40° C.; 0 bar) for 12 hours in order to ensure uniform drying of the complex. Analysis by HPLC for codeine base content, and Karl Fisher for moisture content gave the following results: % codeine base was 14.49%, and the moisture contents was 4.21%. The complex was characterised by DSC, FT-IR and XRD.

후처리

  1. customthe mixture ground together in a mortar with a pestle to form a uniform paste
  2. customGrinding
  3. customThe paste was then dried in a vacuum oven (40° C.; 0 bar) for 48 hours
  4. waitreturned to the vacuum oven (40° C.; 0 bar) for 12 hours in order
  5. customto ensure uniform drying of the complex

출처 및 근거

ORD 기록
ord-5c6c9ca07ab7479dac8a57a451ac11b1
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06255502B1

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