Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isobutylamine → 6-(2-Chloro-4-fluorophenyl)-5-(4-chlorophenyl)-2-(isobutylamino)pyridine-3-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isobutylamine | HCID 6558 | — |
| 반응물 | 2-Chloro-6-(2-chloro-4-fluorophenyl)-5-(4-chlorophenyl)pyridine-3-carbonitrile | HCID 86610502 | — |
| 생성물 | 6-(2-Chloro-4-fluorophenyl)-5-(4-chlorophenyl)-2-(isobutylamino)pyridine-3-carbonitrile | HCID 68718043 | — |
반응 단계
2-chloro-6-(2-chloro-4-fluorophenyl)-5-(4-chlorophenyl)pyridine-3-carbonitrile (prepared from 6-(2-chloro-4-fluorophenyl)-5-(4-chlorophenyl)-1,2-dihydro-2-oxopyridine-3-carbonitrile using conditions similar to Step C Example 1) was reacted with isobutylamine using the conditions of Step A EXAMPLE 27 to afford the title compound. HPLC/MS: 414.1 (M+1), 415.9 (M+3); Rt=4.68 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07728141B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-fd748734de3948cba74050eaef402336 |
| 출처 메모 | uspto-grants-2010_06 |