Isobutylamine → 6-(2-Chloro-4-fluorophenyl)-5-(4-chlorophenyl)-2-(isobutylamino)pyridine-3-carbonitrile

HRID 13838

반응식

HRID 13838 반응식
Cl[C:2]1[C:7]([C:8]#[N:9])=[CH:6][C:5]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=2)=[C:4]([C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:18]=2[Cl:24])[N:3]=1.[CH2:25]([NH2:29])[CH:26]([CH3:28])[CH3:27]>>[Cl:24][C:18]1[CH:19]=[C:20]([F:23])[CH:21]=[CH:22][C:17]=1[C:4]1[N:3]=[C:2]([NH:29][CH2:25][CH:26]([CH3:28])[CH3:27])[C:7]([C:8]#[N:9])=[CH:6][C:5]=1[C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=1

참가 물질

3

반응물 2

HCID 6558IsobutylamineHCID 866105022-Chloro-6-(2-chloro-4-fluorophenyl)-5-(4-chlorophenyl)pyridine-3-carbonitrile

생성물 1

HCID 687180436-(2-Chloro-4-fluorophenyl)-5-(4-chlorophenyl)-2-(isobutylamino)pyridine-3-carbonitrile

실험 절차

2-chloro-6-(2-chloro-4-fluorophenyl)-5-(4-chlorophenyl)pyridine-3-carbonitrile (prepared from 6-(2-chloro-4-fluorophenyl)-5-(4-chlorophenyl)-1,2-dihydro-2-oxopyridine-3-carbonitrile using conditions similar to Step C Example 1) was reacted with isobutylamine using the conditions of Step A EXAMPLE 27 to afford the title compound. HPLC/MS: 414.1 (M+1), 415.9 (M+3); Rt=4.68 min.

출처 및 근거

ORD 기록
ord-fd748734de3948cba74050eaef402336
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728141B2

연결된 노트

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