3-Bromophenol → [2-(3-Bromophenoxy)ethyl]dimethylamine

HRID 1383926

반응식

HRID 1383926 반응식
[Br:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.Cl.[CH3:10][N:11]([CH2:13][CH2:14]Cl)[CH3:12].CN(CCOC1C=CC(Br)=CC=1)C>>[CH3:10][N:11]([CH2:13][CH2:14][O:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[CH:3]=1)[CH3:12]

참가 물질

4

반응물 3

HCID 115633-BromophenolHCID 213877(2-(4-Bromophenoxy)ethyl)dimethylamineHCID 11636816N,N-Dimethylaminoethyl chloride hydrochloride

생성물 1

HCID 413371[2-(3-Bromophenoxy)ethyl]dimethylamine수율 74%

실험 절차

3-Bromophenol (5.0 g, 28.9 mmol) and 2-(N, N-dimethylamino)ethyl chloride, hydrochloride (6.24 g, 43.3 mmol) were reacted by the general procedures as described in the preparation of N,N-dimethyl-2-(4-bromophenoxy)ethylamine. The residue was chromatographed on silica gel (dichloromethane/methanol 100:0 to 90:10) to give the title compound (5.2 g, 74%) as a pale yellow liquid.

후처리

  1. customThe residue was chromatographed on silica gel (dichloromethane/methanol 100:0 to 90:10)

출처 및 근거

ORD 기록
ord-b8e9423d5e1542d4bee4f8582baa6077
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06255496B1

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