2-(4-Methylphenoxy)acetonitrile → HCID 178426841, 화합물

HRID 1384003노트

반응식

HRID 1384003 반응식
[CH3:1][C:2]1[CH:11]=[CH:10][C:5]([O:6][CH2:7][C:8]#[N:9])=[CH:4][CH:3]=1.C[O-].[Na+].Cl.Cl.[NH2:17][C:18]1[C:23](N)=[CH:22][CH:21]=[CH:20][C:19]=1[OH:25]>CO>[OH:25][C:19]1[C:18]2[NH:17][C:8]([CH2:7][O:6][C:5]3[CH:10]=[CH:11][C:2]([CH3:1])=[CH:3][CH:4]=3)=[N:9][C:23]=2[CH:22]=[CH:21][CH:20]=1

참가 물질

5

반응물 3

HCID 5206572-(4-Methylphenoxy)acetonitrileHCID 10942334Sodium MethoxideHCID 184017512,3-Diaminophenol--hydrogen chloride (1/2)

생성물 1

HCID 178426841HCID 178426841, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

In a 50 ml single neck round bottom flask, under a nitrogen atmosphere, 4-methylphenoxyacetonitrile (2.79 mmol) was admixed in methanol (11 ml). The contents were stirred to achieve dissolution. To this solution were added sodium methoxide (0.164 g, 3.0 mmol). The resulting mixture was stirred for about 40 minutes. To this mixture was added 2,3-diaminophenol dihydrochloride salt (0.5 g, 2.5 mmol) and the resulting mixture was stirred for two hours at room temperature. The reaction mixture was filtered and the filtrate was added to 60 ml of water. A light brown precipitate formed and this precipitate is removed by filtration, and washed with 20 ml of water. The solid was dried in a vacuum oven overnight.

후처리

  1. dissolutiondissolution
  2. stirringThe resulting mixture was stirred for about 40 minutes
  3. stirringthe resulting mixture was stirred for two hours at room temperature
  4. filtrationThe reaction mixture was filtered
  5. additionthe filtrate was added to 60 ml of water
  6. customA light brown precipitate formed
  7. customthis precipitate is removed by filtration
  8. washwashed with 20 ml of water
  9. customThe solid was dried in a vacuum oven overnight

출처 및 근거

ORD 기록
ord-64f6caa27e924222ae05f242b8b18d31
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06255494B1

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