Guanidine Hydrochloride → HCID 178432059, 화합물

HRID 1384292노트

반응식

C([O:4][CH:5]1[C:11]2=[N:12][C:13]([CH3:21])=[C:14]([C:16](OCC)=[O:17])[CH:15]=[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6]1)(=O)C.Cl.[NH2:23][C:24]([NH2:26])=[NH:25]>>[OH:4][CH:5]1[C:11]2=[N:12][C:13]([CH3:21])=[C:14]([C:16]([NH:25][C:24]([NH2:26])=[NH:23])=[O:17])[CH:15]=[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6]1

참가 물질

반응물 2

HCID 5742Guanidine Hydrochloride

HCID 21186674HCID 21186674, 화합물

생성물 1

HCID 178432059HCID 178432059, 화합물수율 58.9%

실험 절차

When the method of Inventive Example 1 was repeated using ethyl 9-acetoxy-2-methyl-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine-3-carboxylate (450.0 mg, 1.55 mmol) and guanidine hydrochloride (2.67 g, 28.0 mmol), hydrolysis of the acetoxy group occurred at the same time, and the title compound (237.8 mg, 58.9%) was obtained as white powder.

출처 및 근거

ORD 기록: ord-89501d3bebf44fe6be6637960f55efac
출처 데이터셋: uspto-grants-2001_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06258829B1

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