Aluminum isopropoxide → 3-(3-Isopropylphenyl)butanol

HRID 1384408노트

반응식

HRID 1384408 반응식
CC(C)[O-].[Al+3].CC(C)[O-].CC(C)[O-].[CH:14]([C:17]1[CH:18]=[C:19]([CH:23]([CH3:27])[CH2:24][CH:25]=[O:26])[CH:20]=[CH:21][CH:22]=1)([CH3:16])[CH3:15]>C(O)(C)C.CCOCC>[CH:14]([C:17]1[CH:18]=[C:19]([CH:23]([CH3:27])[CH2:24][CH2:25][OH:26])[CH:20]=[CH:21][CH:22]=1)([CH3:16])[CH3:15]

참가 물질

5

반응물 2

HCID 11143Aluminum isopropoxideHCID 86209Florhydral

생성물 1

HCID 220355223-(3-Isopropylphenyl)butanol수율 73.7%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 3776Isopropanol용매2회

실험 절차

To a refluxing solution of 132.8 g aluminum isopropoxide in 800 ml of isopropanol, a solution of 300 g of 3-(3-isopropylphenyl)butanal in 200 ml of isopropanol was dropped in. The resulting solution was refluxed for 1.5 hours, then cooled and diluted with ether. Then, the organic phase was washed with brine, dried, and evaporated to dryness. The resulting oil was distilled to yield 223.5 g of a colorless oil.

후처리

  1. temperatureThe resulting solution was refluxed for 1.5 hours
  2. temperaturecooled
  3. washThen, the organic phase was washed with brine
  4. customdried
  5. customevaporated to dryness
  6. distillationThe resulting oil was distilled

출처 및 근거

ORD 기록
ord-50b35a20e7ae42c9a03a95b57838f8f4
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06258854B1

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