Thionyl Chloride → 4-Chloro-7-(4-pyridylmethoxy)quinazoline hydrochloride
반응식
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][O:8][C:9]2[CH:18]=[C:17]3[C:12]([C:13](=O)[NH:14][CH:15]=[N:16]3)=[CH:11][CH:10]=2)=[CH:3][CH:2]=1.S(Cl)([Cl:22])=O>CN(C=O)C>[ClH:22].[Cl:22][C:13]1[C:12]2[C:17](=[CH:18][C:9]([O:8][CH2:7][C:4]3[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=3)=[CH:10][CH:11]=2)[N:16]=[CH:15][N:14]=1참가 물질
4
반응 조건
- 온도
- 60 °C
실험 절차
A mixture of 7-(4-pyridylmethoxy)-3,4-dihydroquinazolin-4-one (320 mg, 1.26 mmol), DMF (1 drop) and thionyl chloride (10 ml) was heated at 60° C. for 1 hour. The volatiles were removed by evaporation, the residue was triturated with ether, collected by filtration, washed with ether and dried under vacuum to give 4-chloro-7-(4-pyridylmethoxy)quinazoline hydrochloride (435 mg, 98%). 1H NMR Spectrum (DMSOd6) 5.7(s, 2H); 7.32(s, 1H); 7.35(d, 1H); 8.1-8.2(m, 3H); 8.62(s,1H); 9.0(d, 2H). MS-ESI: 272 [MH]+