Potassium Hydroxide → 5-Nitro-1-benzothiophene-2-carboxylic acid

HRID 1384842

반응식

HRID 1384842 반응식
C([O:3][C:4]([C:6]1[S:10][C:9]2[CH:11]=[CH:12][C:13]([N+:15]([O-:17])=[O:16])=[CH:14][C:8]=2[CH:7]=1)=[O:5])C.[OH-].[K+]>CCO.O>[N+:15]([C:13]1[CH:12]=[CH:11][C:9]2[S:10][C:6]([C:4]([OH:5])=[O:3])=[CH:7][C:8]=2[CH:14]=1)([O-:17])=[O:16]

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 737499Ethyl 5-nitro-1-benzothiophene-2-carboxylate

생성물 1

HCID 2389395-Nitro-1-benzothiophene-2-carboxylic acid수율 85%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

10 g (39.8×10−3 moles) 5-nitrobenzo[b]thiophen-2-carboxylic acid ethyl ester in 250 ml of EtOH and 60 ml of H2O were reacted with 3.8 g (67.8×10−3 moles) of KOH at 60° C. for 2 hours, after which the potassium salt of the product was collected by filtration. A further fraction of the product was collected on adding isopropanol to the filtrate. The salt was dissolved in water and after acidulating the solution with HCl(c), the protonated form of the acid was precipitated out. It was purified by recrystallisation in H2O/EtOH. Yield: 85%.

후처리

  1. filtrationafter which the potassium salt of the product was collected by filtration
  2. customA further fraction of the product was collected
  3. additionon adding isopropanol to the filtrate
  4. dissolutionThe salt was dissolved in water
  5. customthe protonated form of the acid was precipitated out
  6. customIt was purified by recrystallisation in H2O/EtOH

출처 및 근거

ORD 기록
ord-2a480e7db0ff45ca8549bc82c30e3218
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06262056B1

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