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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Isopropanol → 2-[N-(3-Ethoxycarbonylpropyl)-N-methylamino]-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline

HRID 1384914
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HRID 1384914 반응식
Cl.[CH3:2][NH:3][CH2:4][CH2:5][CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8].C(N(CC)CC)C.CC(O)C.Cl[C:24]1[N:33]=[C:32]([NH:34][CH2:35][C:36]2[CH:41]=[CH:40][C:39]3[O:42][CH2:43][O:44][C:38]=3[CH:37]=2)[C:31]2[C:26](=[CH:27][CH:28]=[C:29]([C:45]#[N:46])[CH:30]=2)[N:25]=1>CN(C)C=O>[CH2:10]([O:9][C:7]([CH2:6][CH2:5][CH2:4][N:3]([C:24]1[N:33]=[C:32]([NH:34][CH2:35][C:36]2[CH:41]=[CH:40][C:39]3[O:42][CH2:43][O:44][C:38]=3[CH:37]=2)[C:31]2[C:26](=[CH:27][CH:28]=[C:29]([C:45]#[N:46])[CH:30]=2)[N:25]=1)[CH3:2])=[O:8])[CH3:11]
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참가 물질

6

반응물 4

HCID 3776IsopropanolHCID 8471TriethylamineHCID 14177893Ethyl 4-(methylamino)butanoate hydrochlorideHCID 211839842-Chloro-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline

생성물 1

HCID 220693432-[N-(3-Ethoxycarbonylpropyl)-N-methylamino]-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline수율 77.6%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

858 mg of ethyl N-methyl-4-aminobutyrate hydrochloride, 238 mg of triethylamine, 4 ml of 2-propanol and 2 ml of N,N-dimethylformamide were added to 400 mg of 2-chloro-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline. The obtained mixture was refluxed for 1 hour, cooled to room temperature and filtered. The filtrate was distilled under a reduced pressure to remove the solvent and the residue was recrystallized (from ethanol/water) to give 410 mg of the title compound.

후처리

  1. temperatureThe obtained mixture was refluxed for 1 hour
  2. filtrationfiltered
  3. distillationThe filtrate was distilled under a reduced pressure
  4. customto remove the solvent
  5. customthe residue was recrystallized (from ethanol/water)

출처 및 근거

ORD 기록
ord-2f6c04c33a514243865f760c2d2fb5ab
출처 데이터셋
uspto-grants-2001_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06262059B1

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