Acetone Cyanohydrin → HCID 178463102, 화합물

HRID 1385031

반응식

HRID 1385031 반응식
[Br:1][C:2]1[C:11]2[N:10]=[CH:9][CH:8]=[CH:7][C:6]=2[C:5]([C:12]([OH:14])=O)=[CH:4][CH:3]=1.[CH2:15]([N:17]1[C:21]([OH:22])=[CH:20][CH:19]=[N:18]1)[CH3:16].C1(N=C=NC2CCCCC2)CCCCC1.CC(C)(O)C#N.C(=O)([O-])[O-].[Na+].[Na+]>C(#N)C.C(N(CC)CC)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]([C:20]2[CH:19]=[N:18][N:17]([CH2:15][CH3:16])[C:21]=2[OH:22])=[O:14])=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2

참가 물질

8

반응물 5

HCID 6406Acetone CyanohydrinHCID 10340Sodium CarbonateHCID 10868DicyclohexylcarbodiimideHCID 110213638-bromoquinoline-5-carboxylic AcidHCID 178418331HCID 178418331, 화합물

생성물 1

HCID 178463102HCID 178463102, 화합물

시약·촉매·용매 2

HCID 6342Acetonitrile용매HCID 8471Triethylamine용매

실험 절차

1.00 g of 8-bromoquinoline-5-carboxylic acid, 0.44 g of 1-ethyl-5-hydroxypyrazole and 0.80 g of dicyclohexylcarbodiimide were stirred in 15 ml of acetonitrile at room temperature. After the addition of 0.2 ml of acetone cyanohydrin and 0.60 g of triethylamine, stirring was continued for 1.5 hours and the mixture was then poured into aqueous sodium carbonate solution. The alkaline phase was washed with ethyl acetate and diethyl ether and then acidified. The precipitate was filtered off under suction and the aqueous phase was extracted with ethyl acetate. This organic phase was dried and concentrated. The residue and the precipitate were combined.

후처리

  1. washThe alkaline phase was washed with ethyl acetate and diethyl ether
  2. filtrationThe precipitate was filtered off under suction
  3. extractionthe aqueous phase was extracted with ethyl acetate
  4. customThis organic phase was dried
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-9fdd006d23c84e68816f4a08d800cf40
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06262074B1

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